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Thymocytes positively select thymocytes in human system

E Y Choi1, W S Park, K C Jung

  • 1Department of Pathology, Seoul National University College of Medicine, Korea.

Human Immunology
|April 15, 1997
PubMed
Summary
This summary is machine-generated.

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Human thymocytes expressing MHC class II molecules actively participate in T cell selection. Blocking T cell receptor recognition of MHC class II molecules arrests T cell maturation.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • MHC class II molecules are expressed on human fetal and postnatal thymocytes.
  • Previous findings raised questions about the role of these molecules in immature T cell selection.

Purpose of the Study:

  • To investigate the active involvement of MHC class II+ thymocytes in T cell selection.
  • To determine the role of T-T interactions in T cell maturation.

Main Methods:

  • Development of a human reaggregate culture system.
  • Analysis of T cell maturation and differentiation stages.
  • Blocking of T cell receptor (TCR) recognition of MHC class II molecules.

Main Results:

  • MHC class II+ thymocytes, not just thymic epithelial cells, are involved in T cell selection via T-T interaction.

Related Experiment Videos

  • Maturation to single positive (SP) cells requires MHC class II molecules.
  • Blocking TCR recognition of MHC class II molecules arrested T cells at the double positive (DP) stage.

    • Conclusions:

    • Human MHC class II+ thymocytes play an active role in selecting the T cell receptor (TCR) repertoire.
    • TCR recognition of peptide/MHC class II is a critical initial step in T cell selection.