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The influence of ifosfamide scheduling on acute nephrotoxicity in children
M W English1, R Skinner, A D Pearson
1Sir James Spence Institute of Child Health, The Royal Victoria Infirmary, Newcastle upon Tyne, UK.
British Journal of Cancer
|January 1, 1997
Abstract:
Nephrotoxicity is a significant problem in children after treatment with ifosfamide. Acute changes in renal function were compared in 16 children receiving 9 g m(-2) of ifosfamide as a 72-h continuous infusion on one occasion and, on another course, divided into three 1-h infusions on consecutive days. Subclinical acute nephrotoxicity was demonstrated with both schedules, but there were no significant differences in severity.