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Related Concept Videos

Cancer02:18

Cancer

54.6K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Principles of Drug Action01:24

Principles of Drug Action

9.0K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
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Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

10.6K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.6K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
Drug-Receptor Interaction: Agonist01:25

Drug-Receptor Interaction: Agonist

4.2K
Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
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[Present status and clinical therapy of pancreatic diseases].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·1992
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Reptilian viruses: adenovirus-like agent isolated from royal python (Python regius).

Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B·1992
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Specific stimulation by estradiol of tissue-type plasminogen activator production in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·1992
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Magnocellular neurosecretory neurons with ferritin-like immunoreactivity in the hypothalamic supraoptic and paraventricular nuclei of the rat.

Brain research·1992
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Changes in IL-6, IL-8, C-reactive protein and pancreatic secretory trypsin inhibitor after transcatheter arterial chemo-embolization therapy for hepato-cellular carcinoma.

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Related Experiment Video

Updated: Feb 18, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

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[Anticancer drugs and pharmacologic actions]

M Ogawa1

  • 1Aichi Cancer Center.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 1, 1997
PubMed
Summary

This research explores the diverse classifications of anticancer drugs, detailing their mechanisms like DNA alkylation, antimetabolite interference, and microtubule inhibition. It highlights how these agents target cancer cells through various pathways to induce death or differentiation.

Area of Science:

  • Pharmacology and Molecular Biology
  • Oncology Drug Discovery

Context:

  • Anticancer drugs are essential in cancer treatment.
  • Traditional drug classification relies on mechanism of action or origin.
  • Understanding diverse drug actions is crucial for effective therapy.

Purpose:

  • To review and categorize anticancer drugs based on their mechanisms and origins.
  • To elucidate the specific actions of different drug classes on cellular processes.
  • To provide a comprehensive overview of anticancer drug classification.

Summary:

  • Alkylating agents cross-link DNA, inhibiting replication and transcription.
  • Antimetabolites mimic essential molecules, disrupting DNA/RNA synthesis.
  • Antitumor antibiotics, plant alkaloids (e.g., vinca alkaloids, camptothecins), and other compounds exhibit unique cytotoxic mechanisms.

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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Impact:

  • Facilitates a deeper understanding of anticancer drug action.
  • Aids in the development of novel cancer therapies.
  • Supports the rational design and selection of chemotherapeutic agents.