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Is there acetylcholine receptor in human thymus?

G A Nicholson, S H Appel

    Journal of the Neurological Sciences
    |October 1, 1977
    PubMed
    Summary
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    Human thymus tissue lacks acetylcholine receptors, challenging the theory that these receptors in the thymus cause myasthenia gravis. Studies found no evidence of acetylcholine receptors in normal or myasthenic thymus glands.

    Area of Science:

    • Neuroimmunology
    • Autoimmune Diseases

    Background:

    • Recent studies suggest calf thymus nicotinic acetylcholine receptors (AChRs).
    • Human thymus AChRs could be an antigen source for myasthenia gravis (MG) antibody production.

    Purpose of the Study:

    • To investigate the presence of acetylcholine receptors in human thymus tissue.
    • To determine if human thymus tissue from normal individuals and MG patients contains AChRs.

    Main Methods:

    • Testing human thymus tissue for [125I] alpha-bungarotoxin binding.
    • Utilizing antiserum against human acetylcholine receptors.

    Main Results:

    • Neither normal nor myasthenic human thymus tissue exhibited [125I] alpha-bungarotoxin binding.
    • Antigenic properties of acetylcholine receptors were not detected in human thymus tissue.

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    Conclusions:

    • Human thymus tissue does not appear to possess acetylcholine receptors.
    • The thymus is unlikely to be a primary source of autoantigen in myasthenia gravis.