Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia

J P Aggleton1, R C Saunders

  • 1University of Wales, College of Cardiff, UK. aggleton@cardiff.ac.uk

Memory (Hove, England)
|January 1, 1997
PubMed
Summary

Anterograde amnesia stems from damage to an extended hippocampal system. This system is crucial for episodic memory recall but not necessarily for familiarity-based recognition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory.

Cerebral cortex (New York, N.Y. : 1991)·2019
Same author

Cases of Lithotomy.

The Indian medical gazette·2017
Same author

Treatment of "Prolapsed Funis".

The Indian medical gazette·2017
Same author

Cases of Litholapaxy.

The Indian medical gazette·2017
Same author

Case of Salivary Fistula.

The Indian medical gazette·2017
Same author

Anatomical pathways for auditory memory II: information from rostral superior temporal gyrus to dorsolateral temporal pole and medial temporal cortex.

Frontiers in neuroscience·2015

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Anterograde amnesic syndromes arise from diencephalic and temporal lobe damage.
  • The precise neural underpinnings of memory deficits require further elucidation.

Purpose of the Study:

  • To examine the relationship between diencephalic and temporal lobe pathology in anterograde amnesia.
  • To propose a unified neural system underlying episodic memory deficits.

Main Methods:

  • Review of recent findings on amnesic syndromes.
  • Analysis of animal studies on delayed nonmatching-to-sample tasks.
  • Meta-analysis of amnesic subject performance on recognition memory tests.
  • Examination of primate brain connectivity between medial temporal lobe and medial diencephalon.

Related Experiment Videos

Main Results:

  • A common feature of anterograde amnesia is damage to an extended hippocampal system (hippocampus, fornix, mammillary bodies, anterior thalamic nuclei).
  • Damage to this system impairs episodic information recall.
  • Recognition memory, particularly familiarity judgments, may remain intact with lesions in this system, suggesting reliance on other regions like the rhinal cortex.

Conclusions:

  • The extended hippocampal system is critical for episodic memory recall.
  • Recognition memory involves both familiarity-based and retrieval-based processes, with the extended hippocampal system primarily supporting the latter.