Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of chest trauma

J H Calhoon1, J K Trinkle

  • 1Department of Surgery, University of Texas Health Science Center at San Antonio, USA.

Chest Surgery Clinics of North America
|May 1, 1997
PubMed
Summary

The body

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigation and control of aspergillosis and other filamentous fungal infections in solid organ transplant recipients.

Transplant infectious disease : an official journal of the Transplantation Society·2001
Same author

Calculation of lung flow differential after single-lung transplantation: a transesophageal echocardiographic study.

The American journal of cardiology·2001
Same author

The effects of cardiopulmonary bypass and deep hypothermic circulatory arrest on blood viscoelasticity and cerebral blood flow in a neonatal piglet model.

Perfusion·2000
Same author

Decrease in red blood cell deformability caused by hypothermia, hemodilution, and mechanical stress: factors related to cardiopulmonary bypass.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·1999
Same author

Testing neonate-infant membrane oxygenators with the University of Texas neonatal pulsatile cardiopulmonary bypass system in vitro.

Perfusion·1998
Same author

The type of aortic cannula and membrane oxygenator affect the pulsatile waveform morphology produced by a neonate-infant cardiopulmonary bypass system in vivo.

Artificial organs·1998

Area of Science:

  • Cellular and molecular biology
  • Trauma response
  • Physiology

Background:

  • Historically, systemic physiology and biochemistry explained injury response.
  • Recent findings highlight subcellular and molecular events as critical.
  • Understanding these events is key to trauma research.

Purpose of the Study:

  • To elucidate the complex cellular and molecular mechanisms underlying the body's response to injury.
  • To emphasize the shift from traditional physiological explanations to molecular insights.
  • To identify key cellular interactions in trauma response.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of cellular and molecular pathways involved in injury.
  • Focus on the role of endothelial cells, neutrophils, and platelets.

Main Results:

  • The body exhibits a complex cellular and molecular response to injury.
  • Subcellular and molecular events are crucial in trauma.
  • Endothelial cell interactions with neutrophils and platelets are significant, producing cytokines, free radicals, and adhesion molecules.

Conclusions:

  • The cellular and molecular response to injury is intricate and can lead to multi-organ failure.
  • Molecular events, particularly involving endothelial cells, neutrophils, and platelets, are central to understanding trauma.
  • This understanding is vital for developing new therapeutic strategies.

Related Experiment Videos