Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haemodynamic changes during vasodepressor syncope in children and autonomic function

H Tanaka1, H Yamaguchi, H Tamai

  • 1Department of Pediatrics, Osaka Medical College, Japan.

Clinical Physiology (Oxford, England)
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of Supine-Use Wearable Cyborg for Treatment of Neurogenic Bowel Dysfunction after Spinal Cord Injury.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

A nationwide survey of pediatric acquired demyelinating syndromes in Japan.

Neurology·2016
Same author

Complex molecular genetic abnormalities involving three or more genetic mutations are important prognostic factors for acute myeloid leukemia.

Leukemia·2015
Same author

Development of low-fluorescence thick photoresist for high-aspect-ratio microstructure in bio-application.

Biomicrofluidics·2015
Same author

Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice.

Bone marrow transplantation·2014
Same author

Optimal administration time of intramuscular midazolam premedication.

Journal of anesthesia·2013

Children with orthostatic intolerance experiencing vasodepressor attacks show exaggerated heart rate increases and lower blood pressure upon standing. This suggests low sympathetic activity in resistance vessels contributes to these episodes.

Area of Science:

  • Pediatric Cardiology
  • Autonomic Nervous System Function
  • Hemodynamics

Background:

  • Orthostatic intolerance (OI) affects children and adolescents, characterized by symptoms upon assuming an upright posture.
  • Vasodepressor or vasovagal attacks are a common manifestation of OI, involving a sudden drop in blood pressure and heart rate.
  • Understanding the underlying physiological mechanisms in pediatric OI is crucial for effective management.

Purpose of the Study:

  • To investigate postural hemodynamic changes in children with OI.
  • To identify predictors of vasodepressor attacks in this population.
  • To explore the role of autonomic function in the pathophysiology of OI-related vasodepressor attacks.

Main Methods:

  • Studied 54 children (8-16 years) with OI undergoing orthostatic testing.

Related Experiment Videos

  • Compared hemodynamic parameters (heart rate, blood pressure, cardiac output) between orthostatic-positive and negative groups.
  • Assessed autonomic function using pharmacological studies and measured plasma catecholamines.

    • Main Results:

    • 30% of participants experienced vasodepressor attacks during orthostatic testing.
    • Orthostatic-positive individuals exhibited a greater heart rate increase and slightly lower systolic blood pressure when standing.
    • Higher alpha-adrenoceptor sensitivity in resistance vessels was observed in the orthostatic-positive group.

    Conclusions:

    • An exaggerated heart rate increment during standing is a key predictor of vasodepressor attacks in children.
    • Low sympathetic activity in resistance vessels, combined with an exaggerated heart rate response, is strongly linked to vasovagal and vasodepressor attacks in pediatric OI.
    • Sudden arterial vasodilation appears to be the primary cause of the vasodepressor attack.