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META. 3. A genetic algorithm for metabolic transform priorities optimization
1Chemistry Department, Case Western Reserve University, Cleveland, Ohio, USA.
Journal of Chemical Information and Computer Sciences
|March 1, 1997
Abstract:
META is a knowledge-based expert system that simulates the biotransformation of xenobiotics. It operates with the help of a dictionary (knowledge base) to seek target fragments in a compound and transform them to products. Here, a genetic algorithm is introduced to help build the knowledge base and optimize the performance of the methodology.