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Related Experiment Videos

Polyethylene glycol as a binder for tablets

R C Shah, P V Raman, P V Sheth

    Journal of Pharmaceutical Sciences
    |November 1, 1977
    PubMed
    Summary
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    Polyethylene glycol 6000 effectively binds tablets for direct compression, with five of six formulations remaining stable for three years. Ascorbic acid formulations showed stability for 18 months.

    Area of Science:

    • Pharmaceutical Sciences
    • Materials Science

    Background:

    • Direct compression is a preferred method for tablet manufacturing.
    • Binders are crucial for tablet integrity and performance.
    • Polyethylene glycol (PEG) is a common pharmaceutical excipient.

    Purpose of the Study:

    • To evaluate Polyethylene glycol 6000 (PEG 6000) as a binder for direct compression tablet formulations.
    • To assess the physical properties and long-term stability of tablets manufactured using PEG 6000.

    Main Methods:

    • Eleven tablet formulations were prepared using PEG 6000 as the binder.
    • Tablets were produced via direct compression.
    • Stability was evaluated through actual shelf-life studies over three years.

    Main Results:

    Related Experiment Videos

    • Six of the eleven formulations exhibited excellent compressibility and satisfactory tablet characteristics.
    • Five of these six well-compressed formulations demonstrated stability after three years.
    • The ascorbic acid formulation, while stable, showed stability for up to 18 months.

    Conclusions:

    • Polyethylene glycol 6000 is a suitable binder for direct compression, yielding stable tablets.
    • Actual shelf-life studies are critical for accurate pharmaceutical stability assessment.
    • Formulation-specific factors, like ascorbic acid content, influence long-term stability.