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[Development of the cutaneous nervous system]

R Saxod1, L Pays, F J Hemming

  • 1Laboratoire de Neurobiologie du Développement, CERMO, Université Joseph Fourier, Grenoble, France.

Pathologie-Biologie
|December 1, 1996
PubMed
Summary

Skin innervation develops in patterns around hair follicles and feathers. Epidermal cues, like chondroitin sulfate proteoglycans, guide nerve growth, influencing the final sensory nerve patterns during development.

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Area of Science:

  • Developmental biology
  • Neuroscience
  • Dermatology

Background:

  • Vertebrate skin possesses intricate sensory nerve networks, particularly around appendages like hair and feathers.
  • Nerve development in skin follows segmental patterns originating from spinal nerves, with specific timelines for different species.

Purpose of the Study:

  • To investigate the developmental relationship between skin appendage morphogenesis and sensory nerve pattern formation.
  • To elucidate the molecular mechanisms underlying the precise innervation of skin structures.

Main Methods:

  • Studied mouse and chick embryos, utilizing techniques like X-ray irradiation, neural tube ablation, and hormonal/retinoic acid treatments to disrupt development.
  • Employed in vitro co-cultures of dorsal root ganglia and epidermis with inhibitors and antibodies.
  • Localized specific molecules using antibody-based methods.

Main Results:

  • Demonstrated a strong correlation between feather development and nerve pattern formation.
  • Identified a repulsive effect of the epidermis on nerve fibers, mediated partly by chondroitin sulfate proteoglycans.
  • Localized these proteoglycans at feather bud bases, suggesting a key role in nerve patterning.

Conclusions:

  • Specific nerve patterns in the skin are established through developmentally regulated interactions between growing nerve endings and local cues.
  • Chondroitin sulfate proteoglycans play a crucial role in shaping the fine nerve architecture around feather follicles.
  • Epidermal-derived signals actively guide and pattern sensory innervation during skin development.

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