Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Neuro-immuno-cutaneous system (NICS)]

L Misery1

  • 1INSERM U346, Clinique Dermatologique, Hôpital Edouard Herriot, Lyon, France.

Pathologie-Biologie
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

The neuro-immuno-cutaneous system (NICS) reveals intricate links between the nervous system, immunity, and skin. Destabilization of this system contributes to inflammatory skin diseases like psoriasis and atopic dermatitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suicidal ideation in patients with skin conditions: A multicentre European study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2026
Same author

Validation of the French translation of the Prurigo Control Test (PCT) questionnaire.

Annales de dermatologie et de venereologie·2026
Same author

Pseudolymphoma following laser removal of red tattoo ink.

Annales de dermatologie et de venereologie·2026
Same author

Real-world outcomes of adjuvant therapies in stage III/IV melanoma: Insights from the French RIC-MEL cohort.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Impact of the COVID-19 pandemic on melanoma: A retrospective study from the French clinical database of melanoma patients (RIC-Mel).

Annales de dermatologie et de venereologie·2025
Same author

Validation of the French version of the hidradenitis suppurativa quality of life (HiSQOL) questionnaire.

Annales de dermatologie et de venereologie·2025
Same journal

Pathologie-biologie·2020
Same journal

Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

Pathologie-biologie·2015
Same journal

[Not Available].

Pathologie-biologie·2015
Same journal

Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

Pathologie-biologie·2015
Same journal

Biological diagnosis of diabetes mellitus.

Pathologie-biologie·2015
Same journal

Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

Pathologie-biologie·2015
See all related articles

Area of Science:

  • Dermatology
  • Neuroscience
  • Immunology

Context:

  • The skin is intricately connected with the nervous and immune systems, forming the neuro-immuno-cutaneous system (NICS).
  • Cellular interactions, neuromediator synthesis, and receptor expression highlight the bidirectional communication within the NICS.
  • Nerve fibers and cutaneous cells secrete various neuromediators and neurohormones that influence skin and immune cell functions.

Purpose:

  • To explore the concept and components of the neuro-immuno-cutaneous system (NICS).
  • To elucidate the molecular and cellular interactions between the nervous, immune, and cutaneous systems.
  • To understand the role of NICS destabilization in the pathogenesis of inflammatory skin diseases.

Summary:

  • The neuro-immuno-cutaneous system (NICS) describes the close interplay between the nervous system, immunity, and the skin.

Related Experiment Videos

  • Nerve fibers and skin cells communicate via secreted neuromediators and neurohormones, modulating cellular functions.
  • Destabilization of the NICS is implicated in the induction and maintenance of inflammatory skin conditions such as psoriasis and atopic dermatitis.

    • Impact:

    • Provides a framework for understanding the complex pathophysiology of inflammatory skin diseases.
    • Highlights potential therapeutic targets within the neuro-immune-cutaneous axis.
    • Emphasizes the systemic nature of skin health and disease.