[Primary osteoarthrosis: role of local immunologic responses, ways of correction]

Immunofluorescence was used to study the count of joint synovial membrane cells producing immunoglobulins of major classes (A, M, G) in 30 rabbits on a model of experimental arthrosis and the effects of rumalone, rumalone + indomethacin, and food deprivation. Clinically, the levels of immune responses in patients with primary osteoarthrosis were judged from the content of rumalone-sensitive serum antibodies. The development of experimental arthrosis was found to be followed by a substantial increase in the count of synovial membrane cells locally elaborating immunoglobulins chiefly G and M. With this, the use of pathogenetically substantiated therapy with chondroprotective agents produced a slight effect on the degree of local immune response impairments. Correction of the latter may be made with indomethacin and food deprivation in the experiment, as well as with indomethacin and microwave resonance therapy in the clinical setting.