[Effect of calcium channel blockers on temperature in mice]

In the experiments on SHR mice, verapamil, nifedipine, cinnarizin, fendilin, diltiazem, and nimodipine were tested for their effects on changes in rectal temperatures after intraperitoneal and intracerebroventricular injections. Intraperitoneal nifedipine (2 and 10 mg/kg), fendilin (5 and 20 mg/kg), and cinnarizin (5 and 50 mg/kg) lowered rectal temperatures. The similar effects were shown by nimodipine (2.4 micrograms), diltiazem (100 micrograms), and verapamil (100 micrograms) after their intracerebroventricular injections. It is concluded that the hypothermal effect of calcium antagonists is based on their central and hemodynamic mechanisms.