Effect of pentazocine on pressor responses of epinephrine and levarterenol

In rats anesthetized with pentobarbital, pentazocine potentiated the pressor response of two exogenous amines, epinephrine and levarterenol. Although the mechanism for the pentazocine-induced potentiation of the pressor amines has not been proven, it is speculated that pentazocine may increase the blood pressure response of certain amines by interacting with the sympathetic nervous system.