[Diagnostic problems in prostatic pathology: microglandular lesions and intraductal epithelial proliferations]

In this review, the authors discuss the minimal criteria that allow for the distinction of prostatic adenocarcinoma with special emphasis on nuclear and nucleolar aspects and basal cell layer identification by routine and K 903 immunoperoxidase technique. Differential diagnosis are reviewed including microglandular lesions (adenosis, sclerosing adenosis, atrophy) and intraglandular proliferations (basal cell hyperplasia, clear cell cribriform hyperplasia, intraductal dysplasia). The role of dysplasia as a premalignant lesion is also discussed.