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Postdialysis fatigue

A H Sklar1, L A Riesenberg, A K Silber

  • 1Department of Medicine, Wilson Memorial Regional Medical Center, Johnson City, NY 13790, USA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|November 1, 1996
PubMed
Summary
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Postdialysis fatigue is a common and debilitating symptom for hemodialysis patients. Depression is strongly linked to this fatigue, though the exact relationship requires further study.

Area of Science:

  • Nephrology
  • Clinical Medicine
  • Psychiatry

Background:

  • Postdialysis fatigue (PDF) is a frequently reported yet poorly understood complication of maintenance hemodialysis.
  • Understanding the characteristics and potential predictors of PDF is crucial for improving patient quality of life.

Purpose of the Study:

  • To investigate the demographic and clinicolaboratory features associated with postdialysis fatigue in patients undergoing maintenance hemodialysis.
  • To identify factors that may predict or correlate with the occurrence and severity of PDF.

Main Methods:

  • A cross-sectional study involving 85 patients on maintenance hemodialysis.
  • Utilized validated questionnaires (Kidney Disease Questionnaire, Beck Depression Inventory) and chart review to collect data.
  • Assessed fatigue severity, somatic complaints, and various clinical and laboratory parameters.

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Main Results:

  • Forty-three percent of patients experienced postdialysis fatigue, reporting significant severity and somatic complaints.
  • Fatigue symptoms often began with the first dialysis treatment and required an average of 4.8 hours of rest.
  • Greater use of antihypertensive medications with fatigue as a side effect and higher depression scores were observed in the PDF group (P = 0.007 and P = 0.02, respectively).
  • No significant differences were found in age, sex, renal disease type, comorbidities, dialysis parameters, or most laboratory values.

Conclusions:

  • Postdialysis fatigue is a common and incapacitating symptom in hemodialysis patients.
  • Routine clinical or dialytic parameters do not appear to predict PDF.
  • Depression is significantly associated with PDF, but the causal relationship remains unclear.