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Physiology and pathophysiology of dendritic cells
V Wright-Browne1, K L McClain, M Talpaz
1Department of Bioimmunotherapy, University of Texas, M.D. Anderson Cancer Center, Houston, USA.
Human Pathology
|May 1, 1997
Summary
Dendritic cells, key immune cells, are crucial for immune responses and involved in various diseases. This review details their characteristics and roles in conditions like cancer and viral infections.
Area of Science:
- Immunology
- Cell Biology
Background:
- Dendritic cells (DCs) are critical antigen-presenting cells originating from hematopoietic stem cells.
- They encompass Langerhans' cells and other cells within the lymphoreticular system and organ parenchyma.
Purpose of the Study:
- To review the immunophenotypic, morphological, and functional characteristics of the dendritic cell family.
- To discuss their established and suggested roles in various immune responses and clinical syndromes.
Main Methods:
- Literature review of clinical and laboratory studies.
- Analysis of immunophenotypic, morphological, and functional data.
Main Results:
- Dendritic cells are integral to primary and secondary immune responses.
- They play roles in antitumor immunity, tumor surveillance, graft-versus-host disease, and viral pathogenesis (e.g., HIV).
Conclusions:
- Abnormal dendritic cell proliferation characterizes disorders like Langerhans' cell histiocytosis.
- The review covers malignant disorders associated with dendritic cell transformation and their unique roles in disease.