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Updated: Aug 10, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
Published on: February 1, 2018
The convergence of murein recycling research with beta-lactamase research
1Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA.
Abstract:
The story of how investigation of Escherichia coli cell wall elongation evolved into a study of murein recycling and how this led to the discovery that ampG and ampD were required for both murein recycling and beta-lactamase regulation is chronicled. Preliminary information on two other genes believed to be involved in recycling, nagZ, the structural gene for beta-N-acetylglucosaminidase, and tpl, the presumed structural gene for the hypothetical tripeptide-adding enzyme, is presented. The possibility that recycling of murein fragments serves a signaling function is discussed.
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