Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epidemiologic aspects on antibiotic resistance

N Høiby1

  • 1Rigshospitalet, Copenhagen, Denmark.

Microbial Drug Resistance (Larchmont, N.Y.)
|July 1, 1995
PubMed
Summary

Preventing antibiotic-resistant bacteria spread requires early intervention. Mathematical models show that controlling spread is most effective when resistant bacteria prevalence is below 20%, using isolation and hygiene.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air.

Biofilm·2021
Same author

Antibody response against Mycobacterium avium complex in cystic fibrosis patients measured by a novel IgG ELISA test.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2018
Same author

The accessibility of topical treatment in the paranasal sinuses on operated cystic fibrosis patients assessed by scintigraphy.

Rhinology·2018
Same author

Hyperbaric oxygen therapy augments tobramycin efficacy in experimental Staphylococcus aureus endocarditis.

International journal of antimicrobial agents·2017
Same author

Experimental Pseudomonas aeruginosa mediated rhino sinusitis in mink.

International journal of pediatric otorhinolaryngology·2017
Same author

Individual pharmacokinetic variation leads to underdosing of ciprofloxacin in some cystic fibrosis patients.

Pediatric pulmonology·2017

Area of Science:

  • Epidemiology
  • Infectious Disease Modeling
  • Microbiology

Background:

  • Antibiotic resistance is a growing public health concern driven by increased antibiotic use.
  • The spread of resistant bacteria can be modeled using principles of infectious disease dynamics.
  • Understanding factors influencing epidemic spread is crucial for effective control strategies.

Purpose of the Study:

  • To analyze the mathematical models of infectious disease spread for antibiotic-resistant bacteria.
  • To determine optimal intervention points for controlling resistant bacterial epidemics.
  • To identify effective preventive measures against the spread of resistant strains.

Main Methods:

  • Utilized theoretical epidemic curve calculations.
  • Modeled infectious disease spread based on susceptible and infectious individuals.
  • Incorporated effective contact rates between individuals.

Main Results:

  • Peak incidence of resistant bacterial strains occurs when prevalence is between 20-80%.
  • Epidemic spread accelerates with increased exposed populations and higher contact rates.
  • Intervention is most effective when initiated early, below 20% prevalence.

Conclusions:

  • Early intervention (prevalence <20%) is critical for controlling resistant bacterial spread.
  • Effective control strategies include cohort isolation, reducing group sizes, and enhancing hygiene.
  • These measures have demonstrated efficiency in preventing epidemic outbreaks.

Related Experiment Videos