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Serious infections caused by multiply-resistant Enterococcus faecium

J J Wade1, N Rolando, R Williams

  • 1Dulwich Public Health Laboratory, London, U.K.

Microbial Drug Resistance (Larchmont, N.Y.)
|October 1, 1995
PubMed
Summary
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High-level vancomycin-resistant Enterococcus faecium caused severe infections in three liver transplant patients. These multiply-resistant strains highlight the critical challenges in treating infections in immunocompromised individuals.

Area of Science:

  • Infectious Diseases
  • Transplantation Medicine
  • Microbiology

Background:

  • Enterococcus faecium is a common cause of healthcare-associated infections.
  • High-level vancomycin resistance in enterococci (HLR-VAE) poses significant treatment challenges.
  • Liver transplant recipients are particularly vulnerable to serious infections due to immunosuppression.

Observation:

  • Three liver transplant patients experienced severe intraabdominal infections and recurrent bacteremia.
  • The causative agent was identified as Enterococcus faecium with high-level vancomycin resistance.

Findings:

  • The resistant enterococci strains demonstrated resistance to nearly all tested antibacterials.
  • Pristinamycin was ineffective orally, though one strain showed sensitivity to tetracycline.

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Implications:

  • Clinicians must anticipate and manage infections caused by multiply-resistant enterococci.
  • These cases underscore the critical threat posed by multi-drug resistant organisms in immunocompromised patients, necessitating novel therapeutic approaches.