Disseminated intravascular coagulation in pregnancy

Area of Science:

• Obstetrics and Gynecology
• Hematology

Background:

• Disseminated Intravascular Coagulation (DIC) is a critical obstetric complication.
• It signifies widespread activation of coagulation and fibrinolysis.
• DIC is frequently associated with severe obstetric conditions.

Purpose of the Study:

• To summarize the pathophysiology, diagnosis, and management of DIC in pregnancy.
• To highlight the link between DIC and obstetric disorders.

Main Methods:

• Review of literature on DIC in obstetric patients.
• Analysis of diagnostic criteria for DIC.
• Outline of therapeutic strategies.

Main Results:

• DIC presents as abnormal hemorrhage during pregnancy and postpartum.
• Common causes include abruptio placentae, eclampsia, and retained dead fetus.
• Diagnostic indicators include low fibrinogen/platelets and prolonged clotting times.

Conclusions:

• Prompt diagnosis of DIC is crucial for managing obstetric hemorrhage.
• Identifying and treating the underlying obstetric cause is paramount.
• Therapy involves factor replacement and, sometimes, anticoagulation.