Neuronal damage and its relation to dementia in acquired immunodeficiency syndrome (AIDS)

There are an estimated 21.8 million people infected with human immunodeficiency virus (HIV) worldwide [Weekly Epidemiol Rec 1996; 27:204-208] and 90% of these people will have some form of neuropathological abnormality during the course of acquired immunodeficiency syndrome (AIDS). In this review, we will highlight the primary HIV-associated brain disorders. The role of HIV proteins and cytokines on neuronal damage will be assessed. We will also discuss the role of neuronal loss and functional damage in HIV-associated dementia.