Related Experiment Videos
Apoptosis in renal diseases
A Ortiz1, S González Cuadrado, C Lorz
1Division of Nephrology. Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain.
Abstract:
Abnormalities of cell number are a frequent feature of renal disorders. Cell death is a key factor in the regulation of cell number. Apoptosis is an active form of cell death that is modulated by extracellular lethal and survival signals. Regulation of apoptosis also involves a complex system of sensors of the extracellular signals, triggers of the apoptosis program, effectors of apoptosis as well as intracellular survival factors. This paper first reviews current knowledge on the regulation of apoptosis with particular emphasis on renal cell death. Subsequently, it deals with the role of apoptosis in triggering renal disease and its participation in the progression and resolution of renal disorders. This section includes information on the occurrence of apoptosis and expression of apoptosis-related genes in glomerular injury, acute renal failure, chronic renal atrophy, renal fibrosis, polycystic renal disease and kidney development. The final section presents an overview of possible approaches to the therapeutic manipulation of apoptosis in the kidney.
Insights
Apoptosis, a regulated cell death process, is crucial for maintaining kidney health. Understanding its role in renal disorders offers potential therapeutic strategies for kidney diseases.
Area of Science:
- Nephrology
- Cell Biology
- Molecular Biology
Background:
- Abnormal cell numbers are common in kidney disorders.
- Cell death, particularly apoptosis, is a key regulator of cell number.
- Apoptosis is an active process influenced by external signals and internal factors.
Purpose of the Study:
- To review the regulation of apoptosis with a focus on renal cell death.
- To explore the role of apoptosis in the initiation, progression, and resolution of kidney diseases.
- To outline potential therapeutic interventions targeting apoptosis in the kidney.
Main Methods:
- Literature review of apoptosis regulation in renal contexts.
- Analysis of apoptosis occurrence and gene expression in various renal pathologies.
- Overview of therapeutic strategies for manipulating kidney apoptosis.
Main Results:
- Apoptosis plays a significant role in the pathogenesis and resolution of diverse renal disorders.
- Specific renal conditions like glomerular injury, acute renal failure, and polycystic kidney disease involve apoptosis.
- Apoptosis-related gene expression is altered in these kidney diseases.
Conclusions:
- Apoptosis is a critical factor in renal cell number regulation and kidney disease.
- Targeting apoptosis presents a promising avenue for treating kidney disorders.
- Further research into renal apoptosis mechanisms can guide therapeutic development.