Related Experiment Videos
Pharmacological manipulation of the complement system in human diseases
1Division of Biochemistry and Immunology, Department of Dermatology, Academisch Medisch Centrum, University of Amsterdam, Amsterdam, The Netherlands.
Frontiers in Bioscience : a Journal and Virtual Library
|March 1, 1996
Summary
The complement system defends the body but can cause disease when overactivated. Inhibiting complement with high molecular weight molecules offers a therapeutic strategy for various diseases.
Area of Science:
- Immunology
- Molecular Biology
Background:
- The complement system is a crucial part of innate immunity, protecting against pathogens.
- Dysregulation of complement activation is implicated in numerous autoimmune and immune complex diseases.
- Complement fragments can cause tissue injury and exacerbate disease when inappropriately activated.
Purpose of the Study:
- To review high molecular weight complement inhibitors for therapeutic applications.
- To discuss natural and recombinant complement inhibitory molecules.
Main Methods:
- Review of scientific literature on complement inhibitors.
- Focus on high molecular weight inhibitors (plasma and cell surface).
Main Results:
- Inhibition of complement is a promising approach to halt complement-mediated diseases.
- Development of both synthetic low molecular weight and high molecular weight complement inhibitors is ongoing.
- Several high molecular weight complement inhibitors are already in clinical use.
Conclusions:
- Targeting the complement system with inhibitors can effectively manage complement-mediated diseases.
- High molecular weight complement inhibitors, both natural and recombinant, represent a significant therapeutic avenue.