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Intraarterial thrombolysis in a pig model: a preliminary note
P Kesava1, V Graves, S Salamat
1Department of Radiology, University of Wisconsin Medical School, Madison 53792, USA.
AJNR. American Journal of Neuroradiology
|May 1, 1997
Summary
A new pig model for arterial thrombosis effectively compares thrombolysis methods. Mechanical clot disruption with urokinase injection proved more effective for restoring blood flow than continuous urokinase infusion.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Biomedical Engineering
Background:
- Arterial thrombosis poses a significant clinical challenge, necessitating effective therapeutic strategies.
- Assessing novel thrombolytic interventions requires reliable and reproducible animal models.
Purpose of the Study:
- To establish a porcine model of arterial thrombosis for evaluating thrombolysis techniques.
- To compare the efficacy of continuous proximal urokinase infusion versus mechanical disruption with intrathrombic urokinase injection.
Main Methods:
- A stable femoral artery thrombus was induced in pigs.
- Two thrombolysis approaches were tested: continuous urokinase infusion and mechanical disruption with intrathrombic urokinase injection.
- Control animals were observed for spontaneous thrombus resolution.
Main Results:
- No spontaneous flow restoration occurred in control animals.
- Continuous urokinase infusion failed to reestablish flow.
- Mechanical disruption combined with intrathrombic urokinase injection successfully restored some flow.
- Systemic heparinization enhanced flow restoration in the mechanical disruption group.
Conclusions:
- The developed pig model is suitable for comparative thrombolysis research.
- Mechanical clot disruption with intrathrombic urokinase injection demonstrates superior efficacy over continuous infusion for arterial thrombolysis.