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Related Experiment Videos

Feto-maternal bleeding following coelocentesis

G Makrydimas1, D Lolis, I Georgiou

  • 1Department of Obstetrics and Gynaecology, Ioannina University Hospital, Greece.

Human Reproduction (Oxford, England)
|April 1, 1997
PubMed
Summary

Coelocentesis, an early pregnancy procedure, does not significantly increase the risk of feto-maternal hemorrhage. Maternal serum alpha fetoprotein (AFP) levels remained stable after the procedure, indicating safety.

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Celocentesis for early prenatal diagnosis of hemoglobinopathy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2020

Area of Science:

  • Perinatal Medicine
  • Maternal-Fetal Medicine
  • Obstetrics

Background:

  • Feto-maternal hemorrhage (FMH) is a potential complication of invasive prenatal procedures.
  • Early-gestation procedures require careful risk assessment for FMH.

Purpose of the Study:

  • To evaluate the risk of feto-maternal hemorrhage following coelocentesis.
  • To assess changes in maternal serum alpha fetoprotein (AFP) as an indicator of FMH.

Main Methods:

  • Maternal serum AFP levels were measured in 17 singleton pregnancies before and at 1 and 10 minutes after coelocentesis.
  • Gestational age ranged from 6 to 11 weeks.

Main Results:

  • No significant difference was observed in maternal serum AFP concentrations before and after coelocentesis.

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  • Median AFP levels showed no statistically significant increase post-procedure (P > 0.05).

    • Conclusions:

    • Coelocentesis at 6-11 weeks of gestation is not associated with significant feto-maternal hemorrhage.
    • The procedure appears safe regarding FMH based on AFP marker analysis.