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Inhibition of intermediate-term memory following passive avoidance training in neonate chicks by a presynaptic

W Q Zhao1, H Feng, P Bennett

  • 1Department of Psychology, Monash University, Clayton, Victoria, Australia.

Neurobiology of Learning and Memory
|May 1, 1997
PubMed

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Indirect-acting cholinergic agonists work by interacting with an enzyme called acetylcholinesterase (AChE) in the synaptic cleft. They can be reversible or irreversible inhibitors and have different effects on the enzyme.
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...