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Prevalence of abnormal thyroid function tests in a Down's syndrome population

S Rooney1, E Walsh

  • 1Institute of Psychiatry, London.

Irish Journal of Medical Science
|April 1, 1997
PubMed
Summary

Individuals with Down's syndrome show a high prevalence of thyroid dysfunction. Regular monitoring of thyroid function tests is crucial for early detection and management in this population.

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Area of Science:

  • Endocrinology
  • Genetics
  • Public Health

Background:

  • Thyroid dysfunction is more common in individuals with Down's syndrome.
  • Previous studies indicate a higher prevalence, necessitating further investigation.

Purpose of the Study:

  • To assess the thyroid status of individuals with Down's syndrome.
  • To identify the prevalence of abnormal thyroid function tests in this cohort.
  • To evaluate changes in thyroid status over a three-year period.

Main Methods:

  • Retrospective review of thyroid function tests (TFTs) in 136 individuals with Down's syndrome.
  • Categorization into community-based and residential samples.
  • Follow-up assessment of TFTs after three years.

Main Results:

  • Initially, 13% of individuals had abnormal TFTs, with 5% being established cases and 8% newly identified.
  • After three years, 6.5% continued to show abnormal TFTs, with 5% having diagnosed thyroid disease.
  • A statistically significant increase in abnormal TFTs was observed in the residential sample compared to the community sample.

Conclusions:

  • Individuals with Down's syndrome exhibit a significant prevalence of thyroid dysfunction.
  • Regular monitoring of thyroid function is essential due to the high incidence and variability observed.
  • Residential status may be associated with a higher risk of thyroid abnormalities in this population.

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