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Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups
B R Santos1, M G Monteiro, H R Thomasson
1Department of Pharmacology, Universidade Federal de Uberlandia, Minas Gerais, Brazil.
Alcohol (Fayetteville, N.Y.)
|May 1, 1997
Abstract:
We determined the genotypes of the alcohol dehydrogenase (ALDH) and aldehyde dehydrogenase (ALDH2) loci of different ethnic groups living in Brazil, using saliva DNA amplified by PCR and allele-specific oligonucleotides. Self-reports of flushing reaction after drinking were also studied. The allelic frequencies of ADH2 and ALDH2 were found to be lower than those reported other authors, which might be a result of the admixture origin of the Brazilian population. Variability in facial flushing reaction suggests that other factors play a role in the expression of alcohol-induced flushing.