Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopaminergic and opiate agonists and antagonists differentially decrease multiple schedule responding maintained by

C J Slawecki1, C W Hodge, H H Samson

  • 1Neuroscience Program, Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.

Alcohol (Fayetteville, N.Y.)
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-specific increased reactivity of the PVT and prolonged PVT→CeA circuit engagement following psilocin administration.

Nature communications·2026
Same author

The effects of electronic nicotine vapor on voluntary alcohol consumption in female and male C57BL/6 J mice.

Drug and alcohol dependence·2022
Same author

Delayed developmental changes in neonatal vocalizations correlates with variations in ventral medial hypothalamus and central amygdala development in the rodent infant: effects of prenatal cocaine.

Behavioural brain research·2012
Same author

Describing behavior with ratios of count and time.

The Behavior analyst·2012
Same author

Laryngeal spasm during anaesthesia.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2010
Same author

On the use of hyperpolarized helium MRI for conformal avoidance lung radiotherapy.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2009
Same journal

Regulation of amygdala and dopamine system in naïve and chronic alcohol states.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

The Effects of Developmental Ethanol Exposure & Postnatal Choline Supplementation on Long-Term Choline Metabolism.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Early ethanol exposure during gestation and lactation disrupts gut integrity and enhances ethanol intake in C57BL/6 mice offspring.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Effects of acute alcohol on pain-related activity of the anterior and posterior insular cortices.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Adolescent ethanol exposure produces sex-dependent modulation of ethanol-induced analgesia and cell type-specific vlPAG activation.

Alcohol (Fayetteville, N.Y.)·2026
Same journal

Impact of impaired endogenous neurosteroidogenesis on outcomes following chronic alcohol exposure.

Alcohol (Fayetteville, N.Y.)·2026
See all related articles

This study found that drugs affecting dopamine and opiate systems did not selectively alter responses to sucrose/ethanol versus sucrose. However, responses to the sucrose/ethanol solution were more sensitive to these drug effects.

Area of Science:

  • Neurobiology
  • Behavioral Pharmacology
  • Addiction Research

Background:

  • Ethanol (alcohol) and food consumption share overlapping neurobiological pathways.
  • Understanding these shared mechanisms is crucial for addiction research.

Purpose of the Study:

  • To investigate if dopaminergic or opiate compounds differentially affect responding for sucrose/ethanol compared to sucrose alone.
  • To determine the relative sensitivity of sucrose/ethanol-reinforced behavior to these drug classes.

Main Methods:

  • Long-Evans rats were trained to lever-press for either a sucrose/ethanol solution or a sucrose solution.
  • Rats were administered amphetamine, haloperidol, morphine, or naloxone.
  • Effects on lever pressing and reinforcer intake were analyzed.

Related Experiment Videos

Main Results:

  • The sucrose/ethanol solution was a more efficacious reinforcer than sucrose alone.
  • All tested compounds decreased responding for both solutions.
  • Dose-effect curves were shifted leftward for sucrose/ethanol, indicating greater sensitivity.

Conclusions:

  • Dopaminergic and opiate compounds do not selectively alter responding for sucrose/ethanol versus sucrose.
  • Sucrose/ethanol-maintained responding demonstrates increased sensitivity to the disruptive effects of these drugs.