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[Acute cytolytic hepatitis caused by coumarin. 2 cases]
S Koch1, I Beurton, S Bresson-Hadni
1Service d'Hépatologie et de Soins Intensifs Digestifs, CHRU Jean Minjoz, Besançon.
Gastroenterologie Clinique Et Biologique
|January 1, 1997
Summary
Coumarin, a lymphedema treatment, can cause acute hepatitis. Drug withdrawal led to recovery, indicating coumarin
Area of Science:
- Hepatology
- Pharmacology
- Toxicology
Background:
- Coumarin is a widely prescribed medication for managing lymphedema.
- Lymphedema treatment often involves long-term drug therapy.
Observation:
- Two women experienced jaundice, pruritus, and diarrhea after 5 months of coumarin treatment.
- Significant elevations in serum aminotransferases (ALT) were noted, reaching 30-100 times the normal limit.
Findings:
- The cases suggest a probable link between coumarin use and acute hepatitis.
- Discontinuation of coumarin resulted in rapid clinical and biochemical improvement.
- Re-administration of coumarin in one patient triggered a relapse, confirming drug-induced liver injury.
Implications:
- Coumarin can induce acute cytolytic hepatitis, a serious adverse effect.
- Hepatotoxicity should be considered in patients on coumarin therapy presenting with liver abnormalities.
- Careful monitoring and consideration of alternative treatments may be necessary for patients on coumarin.
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