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Related Experiment Videos

Fixed drug eruption induced by lidocaine and patch testing

J C García1, F Torre, M Sánchez

  • 1Allergy Service, Hospital Ntra. Sra. de Candelaria, Tenerife, Spain.

Journal of Investigational Allergology & Clinical Immunology
|March 1, 1997
PubMed
Summary

Fixed drug eruption (FDE) reappeared in a patient after lidocaine exposure, despite negative initial skin tests. Delayed lesion recurrence confirmed lidocaine as the trigger for this specific drug reaction.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Immunology

Background:

  • Fixed drug eruption (FDE) is a distinct cutaneous drug reaction.
  • It characteristically recurs at the same skin sites upon re-exposure to the causative agent.

Observation:

  • A 27-year-old male presented with recurrent erythema and desquamation on palms, soles, and genitals.
  • These reactions occurred after administration of local anesthetics.

Findings:

  • Standard skin tests for lidocaine, mepivacaine, and bupivacaine were initially negative.
  • Lidocaine challenge 8 hours later provoked lesion recurrence.
  • Patch tests with lidocaine showed delayed recurrence (48 hours) on previously affected and healthy skin.

Implications:

Related Experiment Videos

  • This case highlights the potential for delayed reactions in fixed drug eruptions.
  • It underscores the diagnostic challenge posed by negative initial tests in suspected FDE.
  • Diagnostic protocols for local anesthetic-induced FDE may require extended observation periods.