Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antimicrobial therapy for sinusitis

M D Poole1

  • 1Department of Otolaryngology, University of Texas Medical School at Houston, Houston, Texas 77030, USA.

Otolaryngologic Clinics of North America
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene therapy in plastic and reconstructive surgery.

Current gene therapy·2005
Same author

Assessing diagnostic accuracy and tympanocentesis skills in the management of otitis media.

Archives of pediatrics & adolescent medicine·2001
Same author

Does the sheep mandible relapse following lengthening by distraction osteogenesis?

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2001
Same author

Appropriate antibiotic use in treating respiratory tract infections.

The American journal of managed care·2001
Same author

Expression of growth factors in the mandibular distraction zone: a sheep study.

British journal of plastic surgery·2000
Same author

A quantitative analysis of the effect of insulin-like growth factor-1 infusion during mandibular distraction osteogenesis in rabbits.

British journal of plastic surgery·2000
Same journal

Current State of Button Battery Ingestion Injuries.

Otolaryngologic clinics of North America·2026
Same journal

Diagnostic Algorithm for Eustachian Tube Dysfunction and Indications for Balloon Dilation of the Eustachian Tube.

Otolaryngologic clinics of North America·2026
Same journal

Patulous Eustachian Tube Dysfunction.

Otolaryngologic clinics of North America·2026
Same journal

Revisiting Eustachian Tube Anatomy and Physiology.

Otolaryngologic clinics of North America·2026
Same journal

Glottic Stenosis.

Otolaryngologic clinics of North America·2026
Same journal

Eustachian Tube Disorders in Children.

Otolaryngologic clinics of North America·2026
See all related articles

Rational antibiotic therapy for sinusitis is challenging due to limited trials and evolving bacterial resistance. Analyzing antibiotic activity against bacteria in tissues may help predict treatment success for sinusitis.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Microbiology

Background:

  • Rational antibiotic therapy for sinusitis presents significant challenges.
  • Limited comparative trials, numerous treatment options, industry influence, and changing bacterial resistance patterns complicate treatment decisions.
  • Existing controversies surround antibiotic necessity for uncomplicated sinusitis, therapy duration, and agent efficacy.

Purpose of the Study:

  • To evaluate the complexities and challenges in achieving rational antibiotic therapy for sinusitis.
  • To analyze factors influencing antibiotic efficacy in sinusitis treatment.
  • To assess the predictive value of in vitro activity and tissue concentrations for bacterial eradication.

Main Methods:

  • Review of existing literature on sinusitis treatment and antibiotic efficacy.

Related Experiment Videos

  • Analysis of in vitro antibiotic activity against relevant bacterial pathogens.
  • Comparison of in vitro data with achievable antibiotic tissue concentrations.
  • Consideration of bacterial resistance patterns, particularly multidrug-resistant Streptococcus pneumoniae.

    • Main Results:

    • Few high-powered comparative trials exist for sinusitis antibiotic therapy.
    • Limited data suggest more potent antimicrobials are not necessarily superior.
    • In vitro activity correlated with tissue concentrations can predict bacterial eradication efficacy.
    • Multidrug-resistant pneumococci pose a significant challenge to empiric antibiotic algorithms.

    Conclusions:

    • Achieving rational antibiotic therapy for sinusitis requires careful consideration of multiple factors.
    • Empiric antibiotic selection for sinusitis is complicated by bacterial resistance.
    • Predictive models based on in vitro data and tissue concentrations may guide more effective antibiotic choices.