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A bioactive triterpene from Lantana camara
J T Barre1, B F Bowden, J C Coll
1Chemistry Department, De La Salle University, Manila, Philippines
Phytochemistry
|May 1, 1997
Summary
A novel triterpene from Lantana camara, 22 beta-acetoxylantic acid, demonstrated antimicrobial effects against Staphylococcus aureus and Salmonella typhi. This compound also exhibited antimutagenic properties.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Lantana camara is a medicinal plant with a history of traditional use.
- Triterpenes are a class of organic compounds found in plants, known for diverse biological activities.
- Investigating the chemical constituents of L. camara can lead to the discovery of novel bioactive compounds.
Purpose of the Study:
- To isolate and characterize novel and known triterpenes from Lantana camara.
- To evaluate the antimicrobial activity of isolated compounds.
- To assess the antimutagenic potential of the identified triterpenes.
Main Methods:
- Phytochemical investigation involving extraction and chromatographic separation techniques.
- Structure elucidation of isolated compounds using spectroscopic methods (e.g., NMR, MS).
- Antimicrobial assays against selected bacterial strains (Staphylococcus aureus, Salmonella typhi).
- Antimutagenicity testing using standard assays.
Main Results:
- Isolation of a novel triterpene, 22 beta-acetoxylantic acid, alongside known triterpenes.
- 22 beta-Acetoxylantic acid exhibited significant antimicrobial activity against Staphylococcus aureus and Salmonella typhi.
- Both 22 beta-acetoxylantic acid and 22 beta-dimethylacryloyloxy lantanolic acid displayed notable antimutagenic activity.
Conclusions:
- Lantana camara is a rich source of bioactive triterpenes.
- 22 beta-Acetoxylantic acid is a promising compound with both antimicrobial and antimutagenic properties.
- Further research into these triterpenes could lead to the development of new therapeutic agents.