[Echo-guided biopsy of the transitional zone in the diagnosis of prostatic carcinoma]

Approximately 24% of prostate cancer originate in transition zone. To define the indications for transition zone biopsies from April 1994 to February 1996 we evaluated 112 men ranging in age from 56 to 84 years (mean 67.4). 94 patients presented elevated PSA levels and normal rectal examination (24 with negative prior systematic sextant biopsies). A group included 6 patients with palpable nodularity and normal PSA levels. A third group consisted of 12 men with sonographic abnormalities. Of the 112 patients evaluated 38 (34%) were found to have cancer on the prostate biopsies and 7 (18%) were positive only in sample of transition zone biopsies. We conclude that transition zone biopsies don't substantially improve the cancer detection rates in patients with palpable nodularity or sonographic abnormalities but are useful in patients with elevated PSA levels and/or negative prior systematic sextant biopsies.