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Cholesterol homeostasis: clipping out a slippery regulator
1Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, USA.
Current Biology : CB
|March 1, 1997
Abstract:
SREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has shown that a two-step cleavage of membrane-bound SREBPs frees them to enter the nucleus. An activator of the first, sterol-regulated proteolysis step has also been identified.