Related Experiment Videos
Autoimmunity: when self-tolerance breaks down
1Department of Medicine, Center for Immunology at the University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.
Current Biology : CB
|April 1, 1997
Abstract:
The spontaneous development of destructive polyarthritis in mice transgenic for an autoreactive T-cell receptor supports the notion that a failure of T-cell self-tolerance can lead to similar diseases in humans, and sheds new light on the role of peripheral tolerance in the avoidance of such pathological immune responses.