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[Diffuse peritoneal leiomyomatosis. A clinical case report]

G Borsellino1, P Zante, M C Ciraldo

  • 1Divisione di Ostetricia e Ginecologia, Ospedale Provinciale Generale, Azienda USSL 4, Saronno, Varese.

Minerva Ginecologica
|January 1, 1997
PubMed
Summary
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Leiomyomatosis peritonealis disseminata (LPD) is a rare hormonal condition causing benign tumors. A conservative approach is often recommended, but vigilance for malignant changes is crucial.

Area of Science:

  • Gynecology
  • Pathology
  • Oncology

Background:

  • Leiomyomatosis peritonealis disseminata (LPD) is a rare condition characterized by multiple peritoneal leiomyomas.
  • It typically affects women of reproductive age and is presumed to have a hormonal etiology.
  • LPD presents grossly as malignant but is histologically benign.

Observation:

  • A case of LPD in a 25-year-old nulliparous woman with abdominal pain is presented.
  • Pelvic examination and exploratory laparotomy revealed a pelvic mass and peritoneal nodules.
  • The patient underwent surgery, with no further therapy, and was monitored via ultrasound.

Findings:

  • After a 4-year follow-up, the patient remained well and achieved pregnancy.
  • The literature documents approximately 50 LPD cases, with potentially more asymptomatic instances.

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  • Malignant degeneration is reported in about 10% of LPD cases.

    • Implications:

    • A conservative management approach is generally recommended for LPD.
    • Given the risk of malignant degeneration, aggressive follow-up is advised when fertility preservation is desired.
    • Recurrence is the most unfavorable prognostic factor in LPD.