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[Leukocyte migration during erythrocyte sedimentation]

L Bogár1, J A Horváth, M Tekeres

  • 1Pécsi Orvostudományi Egyetem Anaesthesiologiai és Intenzív Therapiás Intézet.

Orvosi Hetilap
|April 6, 1997
PubMed
Summary

A new method measures leukocyte sedimentation, revealing higher rates in patients than healthy individuals. This leukocyte antisedimentation rate (LAR) correlates with other blood properties and is reduced by certain drugs.

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Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Leukocyte sedimentation properties are crucial in understanding blood dynamics.
  • A simple, reproducible method for assessing these properties is needed.

Purpose of the Study:

  • To introduce and validate a novel method for measuring leukocyte sedimentation.
  • To evaluate the leukocyte antisedimentation rate (LAR) in healthy adults and patients.

Main Methods:

  • Developed a new method to measure leukocyte concentration in the upper 100 mm of a blood column after one hour of gravity sedimentation.
  • Expressed the result as leukocyte antisedimentation rate (LAR) percentage.
  • Analyzed blood samples from 35 healthy adults and a mixed patient group.

Main Results:

  • Healthy adults showed a 12.5% increment in total leukocyte count and 17.4% in granulocytes in the upper blood column.
  • The mean coefficient of variation for LAR measurements was 3.2%.
  • LAR was significantly higher in patients compared to healthy controls and correlated with leukocyte adherence, whole blood viscosity, hematocrit, and erythrocyte sedimentation rate.

Conclusions:

  • The new LAR method is simple, reproducible, and effective for assessing leukocyte sedimentation.
  • Elevated LAR in patients suggests altered leukocyte behavior, potentially linked to various clinical conditions.
  • In vitro studies showed prednisolone and lidocaine significantly decrease LAR in a concentration-dependent manner.

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