Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Herpesviruses and AIDS

P D Griffiths1

  • 1Virology Department, Royal Free Hospital School of Medicine, London, UK.

Scandinavian Journal of Infectious Diseases. Supplementum
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Herpesviruses may worsen human immunodeficiency virus (HIV) disease by acting as cofactors. Inhibiting these viruses with aciclovir might explain survival benefits seen in AIDS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccines for SARS coronavirus 2 and the new normal in vaccinology.

Reviews in medical virology·2021
Same author

Post-mortem confirmation of fetal brain abnormalities: challenges highlighted by the MERIDIAN cohort study.

BJOG : an international journal of obstetrics and gynaecology·2020
Same author

Review of the MRI brain findings of septo-optic dysplasia.

Clinical radiology·2020
Same author

SARS coronavirus 2; how many more examples do we need before the world commits to decisive action?

Reviews in medical virology·2020
Same author

Analysis of 270 fetuses with non-visualization of cavum septi pellucidi and vergae on in-utero magnetic resonance imaging.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019
Same author

The rate of brain abnormalities on in utero MRI studies in fetuses with normal ultrasound examinations of the brain and calculation of indicators of diagnostic performance.

Clinical radiology·2019
Same journal

Annual disease burden due to human papillomavirus 16 and 18 infections in Finland.

Scandinavian journal of infectious diseases. Supplementum·2009
Same journal

Annual disease burden due to human papillomavirus (HPV) 6 and 11 infections in Finland.

Scandinavian journal of infectious diseases. Supplementum·2009
Same journal

Supreme Court decision on genotypic tests for antiretroviral drugs resistance: Joint Criminal Divisions.

Scandinavian journal of infectious diseases. Supplementum·2004
Same journal

Brief summary of the legal proceeding.

Scandinavian journal of infectious diseases. Supplementum·2004
Same journal

Too early or too late: a never-ending dilemma with new technologies.

Scandinavian journal of infectious diseases. Supplementum·2004
Same journal

Genotypic resistance tests for the management of postexposure prophylaxis.

Scandinavian journal of infectious diseases. Supplementum·2004
See all related articles

Area of Science:

  • Virology
  • Immunology
  • Oncology

Background:

  • Herpesviruses are known to cause opportunistic infections in patients with Acquired Immunodeficiency Syndrome (AIDS).
  • Emerging evidence suggests herpesviruses may act as cofactors, exacerbating Human Immunodeficiency Virus (HIV) pathogenicity.

Purpose of the Study:

  • To explore the potential role of herpesviruses as cofactors in HIV disease progression.
  • To investigate mechanisms by which herpesviruses might influence HIV pathogenesis.
  • To correlate the presence of specific herpesviruses in AIDS patients with potential therapeutic implications.

Main Methods:

  • Review of in vitro experimental findings on herpesvirus-HIV interactions.
  • Analysis of human autopsy data from AIDS patients.

Related Experiment Videos

  • Correlation of herpesvirus presence with clinical outcomes and antiviral therapy.

    • Main Results:

    • In vitro studies demonstrate herpesviruses can activate HIV gene expression and alter cellular tropism via multiple mechanisms.
    • Autopsy studies reveal frequent co-occurrence of cytomegalovirus, human herpes virus 6, and herpes simplex virus in AIDS patients.
    • The presence of these herpesviruses in vivo suggests a potential cofactor role.

    Conclusions:

    • Herpesviruses may act as cofactors, increasing HIV pathogenicity.
    • Inhibition of these herpesviruses, for example, by aciclovir, could contribute to observed survival benefits in AIDS patients.
    • Further research is warranted to confirm the in vivo cofactor role and therapeutic potential of antiviral agents.