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Updated: Jul 23, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
Published on: March 8, 2013
[Scintigraphy studies of lymph flow in paralyzed upper extremities]
G T Werner1, W Gerhards, H Ingrisch
1Abteilung für Physikalische Medizin und Medizinische Rehabilitation, Städtisches Krankenhaus München-Bogenhausen.
Edema in paralyzed limbs is common but not caused by lymphedema. Increased lymphatic flow in hemiplegic arms suggests autonomic nervous system dysfunction, impacting fluid balance.
Area of Science:
- Medical Science
- Physiology
- Rehabilitation Medicine
Background:
- Edema is frequently observed in paralyzed limbs, complicating patient rehabilitation.
- The underlying causes of edema in hemiplegic limbs remain unclear.
Purpose of the Study:
- To investigate the origin of edema in paralyzed limbs of hemiplegic patients.
- To differentiate edema in hemiplegia from lymphedema.
Main Methods:
- Study included 48 patients with hemiplegia and arm edema.
- Lymphoscintigraphic studies (static and dynamic lymphography) were conducted in 40 patients.
Main Results:
- Lymphatic flow in the paralyzed arm was increased in 80% of cases compared to the healthy arm.
- A significant correlation was observed between marked edema and increased lymphatic flow (p < 0.01).
Conclusions:
- Edema in hemiplegic extremities is unlikely to be lymphedema, which typically presents with slow lymph flow.
- The findings suggest edema is caused by filtration and reabsorption disorders linked to autonomic nervous system dysfunction.
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