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[An epileptic syndrome in infantile cerebral palsy]
Insights
This study examines infantile cerebral paralysis (ICP) with epileptic syndrome (ES) in 102 children. Findings reveal common seizure types and correlations aiding prognosis and treatment strategies.
Area of Science:
- Neurology
- Pediatrics
- Epileptology
Background:
- Infantile cerebral paralysis (ICP) frequently co-occurs with epileptic syndrome (ES).
- Understanding the interplay between ICP and ES is crucial for effective patient management.
Purpose of the Study:
- To analyze the clinical characteristics and course of epileptic syndrome in children with infantile cerebral paralysis.
- To establish correlations between neuroimaging (CT) and electrophysiological (EEG) findings and ES in ICP patients.
- To elucidate pathogenetic mechanisms and inform therapeutic strategies and prognosis.
Main Methods:
- Retrospective analysis of 102 patients diagnosed with ICP and ES.
- Clinical assessment of seizure types, age of onset, and disease progression.
- Correlation analysis using electroencephalography (EEG) and computed tomography (CT) scans.
Main Results:
- Epileptic fits were most prevalent in hemiparetic ICP (40.8%) and spastic diplegia (32.4%).
- ES manifestations typically appeared within the first three years of life (over 80% of cases).
- Distinct seizure types were identified based on age of onset, with specific transformations and prognoses.
- Significant correlations were found between CT/EEG findings and different ICP forms, aiding in understanding ES pathogenesis.
Conclusions:
- Early-onset ES is common in ICP, particularly in hemiparetic and spastic diplegic forms.
- Age-dependent seizure patterns and their transformations are key determinants of prognosis in ICP with ES.
- CT and EEG correlations provide insights into ES pathogenesis, guiding therapeutic decisions and prognostic assessments.
Abstract:
The results of examination of 102 patients with infantile cerebral paralysis (ICP) with epileptic syndrome (ES) at the age from 3 months to 14 years are presented. Epileptic fits predominated in patients with hemiparetic form of ICP (40.8%) and spastic diplegia (32.4%). ES manifestations were observed in ICP during the first 3 years of life (more than 80% of cases). The peculiarities of ES clinical course were revealed. There were determined the main types of seizures in patients with ICP which depended on age of their manifestation, as well as their further transformation and prognosis. Computer tomographic and EEG-correlations were established in different forms of ICP. They permitted to revealed pathogenetic mechanisms of ES development in patients with ICP and to determine therapeutic policy and prognosis of the disease.