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Related Experiment Videos

[S-(+)-Ketamine and circulation]

S Zielmann1, S Kazmaier, S Schnüll

  • 1Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin der Universität Göttingen.

Der Anaesthesist
|March 1, 1997
PubMed
Summary
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S-(+) ketamine offers double the analgesic potency of racemic ketamine, potentially reducing side effects. However, studies show comparable circulatory side effects, suggesting caution in patients with cardiovascular conditions.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Cardiovascular Medicine

Background:

  • S-(+) ketamine, a more potent isomer, may allow for reduced dosages compared to racemic ketamine.
  • Potential reduction in side effects is a key consideration for clinical application.
  • Circulatory side effects of S-(+) ketamine versus racemic ketamine require thorough investigation.

Purpose of the Study:

  • To compare the circulatory side effects of S-(+) ketamine and racemic ketamine.
  • To assess hemodynamic changes in response to S-(+) ketamine and racemic ketamine administration.
  • To evaluate the safety profile of S-(+) ketamine in different patient populations.

Main Methods:

  • Prospective, randomized, double-blinded studies were conducted.
  • Hemodynamic parameters including heart rate (HR) and arterial blood pressure (ABP) were monitored.

Related Experiment Videos

  • Plasma levels of adrenaline (A) and noradrenaline (NA) were measured.

    • Main Results:

    • Both S-(+) ketamine and racemic ketamine caused significant increases in HR and ABP.
    • No significant differences in hemodynamic changes were observed between the two forms of ketamine.
    • Adverse events like severe arterial hypertension occurred in both groups, necessitating withdrawal from studies.

    Conclusions:

    • S-(+) ketamine and racemic ketamine exhibit comparable pharmacodynamic effects regarding hemodynamics.
    • Neither S-(+) ketamine nor racemic ketamine is recommended for patients with pre-existing conditions such as arterial hypertension or coronary artery disease.
    • Careful patient selection and monitoring are crucial when administering ketamine derivatives.