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Related Experiment Videos

Breathing pattern during bronchial challenge in humans

N E Meessen1, C P van der Grinten, S C Luijendijk

  • 1Dept of Pulmonary Diseases, University Hospital Nijmegen, Dekkerswald, Groesbeek, The Netherlands.

The European Respiratory Journal
|May 1, 1997
PubMed
Summary

Histamine inhalation affects breathing patterns differently in individuals with and without airway hyperresponsiveness. These varied responses in minute ventilation, respiratory frequency, and tidal volume highlight opposing physiological mechanisms at play.

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Area of Science:

  • Respiratory Physiology
  • Pulmonary Medicine
  • Clinical Investigation

Background:

  • Asthma exacerbations and histamine administration are known to increase minute ventilation (V'E).
  • The precise impact of histamine on breathing patterns, including respiratory frequency (fR) and tidal volume (VT), remains unclear.
  • Variability in V'E responses suggests complex underlying physiological mechanisms.

Purpose of the Study:

  • To investigate the effects of inhaled histamine on fR, VT, V'E, and functional residual capacity (FRC).
  • To compare these effects in subjects with (BHR+) and without (BHR-) bronchial hyperresponsiveness.
  • To elucidate the mechanisms influencing breathing pattern changes in response to histamine.

Main Methods:

  • 63 human subjects (44 BHR+, 19 BHR-) inhaled histamine.

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  • Measurements included fR, VT, V'E, and FRC.
  • Bronchial hyperresponsiveness was defined by a >20% decrease in forced expiratory volume in one second (FEV1) after histamine.

    • Main Results:

    • Histamine significantly increased fR in both BHR+ and BHR- groups.
    • V'E increased significantly in BHR- but not in BHR+ subjects.
    • Responses in V'E, fR, and VT were variable, with comparable numbers of subjects showing increases or decreases.
    • FRC increased significantly more in BHR+ than in BHR- subjects.

    Conclusions:

    • Histamine inhalation elicits variable breathing pattern responses due to simultaneous opposing mechanisms.
    • Excitation of respiratory centers and bronchoconstriction contribute to these opposing effects.
    • Individual responses depend on the net balance between these competing physiological influences.