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Synthesis and biological activity of nifuroxazide and analogs
L C Tavares1, T C Penna, A T Amaral
1Departamento de Tecnologia Bioquímico-Farmacêutica, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brasil.
Bollettino Chimico Farmaceutico
|March 1, 1997
Abstract:
Nifuroxazide and thirteen analogs were synthesized from substituted benzoic acids and minimal inhibitory concentrations were determined using the serial dilution tests, in three sequential steps. Nifuroxazide and chloramphenicol were used as reference standards. The tests were performed in TSB against the standard bacterial strain of Staphylococcus aureus ATCC 25923.