Diet, anthropometry and breast cancer: integration of experimental and epidemiologic approaches

The interrelation ships of dietary fat and energy, growth rates and anthropometry, and breast carcinogenesis have been examined by a diverse array of approaches throughout the last 50 y as new investigative tools have been developed by laboratory scientists and epidemiologists. A consensus among investigators has not emerged, however, and dietary recommendations for breast cancer prevention have not been clearly formulated or effectively communicated to the public. Indeed, the gap between those investigators utilizing laboratory-based approaches and those using epidemiologic models has expanded in recent years. Cancer epidemiologists have become increasingly skeptical that results derived form laboratory animal models of breast carcinogenesis and in vitro systems are directly applicable to human breast cancer risk. Concurrently, laboratory scientists have questioned the ability of epidemiological tools to accurately measure dietary intake and relevant biomarkers and to account for a diverse array of potentially confounding environmental and genetic factors characteristic of human populations under study. These polarized views are reinforced by a failure of investigators using diverse approaches to interact, integrate their skills and resources, develop novel hypotheses, and propose solutions using both laboratory and epidemiologic techniques. Therefore, the objectives of this symposium are to summarize experimental and epidemiologic knowledge, foster communication and collaboration, and attempt to identify appropriate studies to bridge the gaps in our knowledge concerning dietary lipid and energy, anthropometrics, and breast cancer risk.