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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Cancer of the colon and rectum in the first three decades of life

M D Shahrudin1, S M Noori

  • 1Department of Surgery; Royal Postgraduate Medical School, United Kingdom.

Hepato-Gastroenterology
|March 1, 1997
PubMed

Insights

Colorectal cancer in patients 30 years or younger is uncommon but presents with advanced disease. Early recognition of symptoms like abdominal pain and rectal bleeding is crucial for timely diagnosis.

Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • An increasing incidence of colorectal carcinoma in young patients (≤30 years) has been observed.
  • This study details the experience with this demographic at University Hospital, Kuala Lumpur.

Purpose of the Study:

  • To analyze the clinical characteristics, treatment, and outcomes of colorectal cancer in patients aged 30 years or younger.
  • To raise awareness among clinicians regarding this rare presentation of colorectal cancer.

Main Methods:

  • A retrospective review of all primary colorectal carcinoma cases admitted between 1990 and 1994.
  • Inclusion criteria: patients aged 30 years or younger at diagnosis.
  • Data collected: demographics, tumor site, symptoms, histology, disease extent, and survival.

Main Results:

  • Twenty-one patients (mean age 20-29 years) were included; 67% were Chinese, and 57% were female.
  • Tumors were frequently located in the rectosigmoid (29%) or cecum (24%).
  • The 5-year survival rate was 25%, with most patients presenting with extensive disease and mucinous histology.

Conclusions:

  • Colorectal cancer in young patients often presents with advanced disease, commonly beyond the transverse colon.
  • Key presenting symptoms include abdominal pain, hematochezia, or positive fecal occult blood tests.
  • These symptoms warrant consideration of colorectal carcinoma in the differential diagnosis for young patients.
Abstract

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