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Related Experiment Videos

Complementary medical treatment for Colles' fracture: a comparative, randomized, longitudinal study

R Crespo1, M Revilla, E Crespo

  • 1Department of Medicine, University of Alcalá de Henares, 28801 Madrid, Spain.

Calcified Tissue International
|June 1, 1997
PubMed
Summary

This study found that calcitonin with calcium supplements effectively increased bone mass in women with Colles

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Area of Science:

  • Orthopedics
  • Endocrinology
  • Gerontology

Background:

  • Colles' fracture is a common injury, particularly in postmenopausal women, often leading to bone loss.
  • Osteoporosis significantly increases fracture risk and complicates recovery.
  • Complementary medical treatments are explored to mitigate bone loss post-fracture.

Purpose of the Study:

  • To evaluate the efficacy of calcitonin with calcium (SCT+Ca) versus calcium alone (Ca) compared to placebo.
  • To assess the impact on bone metabolism and bone mass after a Colles' fracture.

Main Methods:

  • A randomized controlled trial involving 45 women with Colles' fracture.
  • Three groups: SCT+Ca, Ca alone, and placebo, each with 15 participants.
  • Biochemical and radiogrammetric assessments were conducted at baseline and after 1 year.

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Main Results:

  • The SCT+Ca group showed a decrease in tartrate-resistant acid phosphatase and an increase in metacarpal index and cortical area to total area ratio.
  • Calcium alone showed no significant changes in bone parameters compared to baseline.
  • The placebo group exhibited a decrease in metacarpal index and cortical area to total area ratio, indicating bone loss.

Conclusions:

  • Calcium alone, at the tested dosage, inhibited bone loss following a Colles' fracture.
  • The addition of calcitonin to calcium supplementation not only prevented bone loss but also significantly enhanced cortical bone mass.
  • SCT+Ca demonstrates a superior therapeutic effect in preserving and improving bone quality after Colles' fracture.