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Isometric handgrip exercise increases endothelin-1 plasma levels in patients with chronic congestive heart failure
E Mangieri1, G Tanzilli, F Barillà
1II Cattedra di Cardiologia, Istituto di Chirurgia del Cuore e Grossi Vasi, Università La Sapienza, Rome, Italy.
The American Journal of Cardiology
|May 1, 1997
Abstract:
This study demonstrated an immediate and short-lasting endothelin-1 release in the circulation of patients with severe chronic congestive heart failure during isometric handgrip exercise, but not in normal subjects. Our data suggest that endothelin-1 levels may increase transiently during daily physical activity, thus contributing to progressive deterioration of left ventricular function.