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Regulation of the RAG-1 promoter by the NF-Y transcription factor
S T Brown1, G A Miranda, Z Galic
1Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California at Los Angeles, 90095, USA.
Abstract:
We have cloned the RAG-1 promoter region and have determined that almost all detectable promoter activity resides within a 208-bp fragment. Sequence analysis of this promoter region has identified potential recognition motifs for a number of lymphocyte-restricted and ubiquitous transcription factors. Subsequent assays have revealed that the NF-Y transcription factor interacts with a CCAAT site within the RAG-1 promoter and appears to play an important role in the positive transcriptional regulation of this gene.
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